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1.
Bone Joint J ; 106-B(2): 158-165, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38425310

RESUMO

Aims: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. Methods: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality. Results: Out of a total of 1,667 patients in the PPF study database, 420 patients were included. The in-hospital mortality rate was 6.4%. Multivariable analyses suggested that American Society of Anesthesiologists (ASA) grade, history of peripheral vascular disease (PVD), history of rheumatic disease, fracture around a loose implant, and cerebrovascular accident (CVA) during hospital stay were each independently associated with mortality. Each point increase in ASA grade independently correlated with a four-fold greater mortality risk (odds ratio (OR) 4.1 (95% confidence interval (CI) 1.19 to 14.06); p = 0.026). Patients with PVD have a nine-fold increase in mortality risk (OR 9.1 (95% CI 1.25 to 66.47); p = 0.030) and patients with rheumatic disease have a 6.8-fold increase in mortality risk (OR 6.8 (95% CI 1.32 to 34.68); p = 0.022). Patients with a fracture around a loose implant (Unified Classification System (UCS) B2) have a 20-fold increase in mortality, compared to UCS A1 (OR 20.9 (95% CI 1.61 to 271.38); p = 0.020). Mode of management was not a significant predictor of mortality. Patients managed with revision arthroplasty had a significantly longer length of stay (median 16 days; p = 0.029) and higher rates of return to theatre, compared to patients treated nonoperatively or with fixation. Conclusion: The mortality rate in PPFs around the knee is similar to that for native distal femur and neck of femur fragility fractures. Patients with certain modifiable risk factors should be optimized. A national PPF database and standardized management guidelines are currently required to understand these complex injuries and to improve patient outcomes.


Assuntos
Artroplastia do Joelho , Fraturas do Fêmur , Fraturas Periprotéticas , Doenças Reumáticas , Adulto , Humanos , Fraturas Periprotéticas/etiologia , Articulação do Joelho/cirurgia , Joelho/cirurgia , Artroplastia do Joelho/efeitos adversos , Fraturas do Fêmur/cirurgia , Doenças Reumáticas/etiologia , Doenças Reumáticas/cirurgia , Estudos Retrospectivos , Reoperação
2.
Sensors (Basel) ; 23(23)2023 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-38067745

RESUMO

The increasing reliance on cyber-physical systems (CPSs) in critical domains such as healthcare, smart grids, and intelligent transportation systems necessitates robust security measures to protect against cyber threats. Among these threats, blackhole and greyhole attacks pose significant risks to the availability and integrity of CPSs. The current detection and mitigation approaches often struggle to accurately differentiate between legitimate and malicious behavior, leading to ineffective protection. This paper introduces Gini-index and blockchain-based Blackhole/Greyhole RPL (GBG-RPL), a novel technique designed for efficient detection and mitigation of blackhole and greyhole attacks in smart health monitoring CPSs. GBG-RPL leverages the analytical prowess of the Gini index and the security advantages of blockchain technology to protect these systems against sophisticated threats. This research not only focuses on identifying anomalous activities but also proposes a resilient framework that ensures the integrity and reliability of the monitored data. GBG-RPL achieves notable improvements as compared to another state-of-the-art technique referred to as BCPS-RPL, including a 7.18% reduction in packet loss ratio, an 11.97% enhancement in residual energy utilization, and a 19.27% decrease in energy consumption. Its security features are also very effective, boasting a 10.65% improvement in attack-detection rate and an 18.88% faster average attack-detection time. GBG-RPL optimizes network management by exhibiting a 21.65% reduction in message overhead and a 28.34% decrease in end-to-end delay, thus showing its potential for enhanced reliability, efficiency, and security.

3.
Saudi J Med Med Sci ; 11(4): 299-304, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37970462

RESUMO

Background: Prostate cancer screening with prostate-specific antigen (PSA) can result in unnecessary biopsies and overdiagnosis. Alternately, PSA density (PSAD) calculation may help support biopsy decisions; however, evidence of its usefulness is not concrete. Objective: To evaluate the predictive value of PSAD for clinically significant prostate cancer detection by systematic and MRI-targeted biopsies. Methods: This prospective study was conducted at two tertiary hospitals in Riyadh, Saudi Arabia, between December 2018 and November 2021. Patients suspected of prostate cancer were subjected to multi-parametric MRI, and for those with positive findings, systematic and targeted biopsies were performed. Clinically non-significant and significant prostate cancer cases were classified based on histopathology-defined ISUP grade or Gleason score. The PSAD was measured using the prostate volume determined by the MRI and categorized into ≤0.15, 0.16-0.20, and >0.20 ng/ml2 subgroups. Results: Systematic and targeted biopsies were carried out for 284 patients. The discriminant ability of PSAD is higher in MRI-targeted biopsy compared with systematic biopsy (AUC: 0.77 vs. 0.73). The highest sensitivity (97%) and specificity (87%) were detected at 0.07 ng/ml2 in targeted biopsy. More than half of the clinically significant cases were detected in the >0.2 ng/ml2 PSAD category (systematic: 52.4%; targeted: 51.1%). The CHAID methodology found that the probability of having clinically significant cancer (CSC) in patients with PSAD >0.15 ng/ml2 was more than threefold than that in patients with PSAD ≤0.15 ng/ml2 (64% vs. 20.2%). When considered by age, in PSAD ≤0.15 ng/ml2 subgroup, the percentage of CSC detection rate increased from 20.2% to 24.6% in patients aged ≥60 years. Conclusion: PSAD has good discriminant power for predicting clinically significant prostate cancer. A cutoff of 0.07 ng/ml2 should be adopted, but should be interpreted with caution and by considering other parameters such as age.

4.
Injury ; 54(12): 111152, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37939635

RESUMO

INTRODUCTION: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital mortality of PPFs involving the hip. METHODS: Using a multi-centre cohort study design, we retrospectively identified adults presenting with a PPF around the hip over a 10-year period. Univariate and multivariable logistic regression analyses were performed to study the independent correlation between patient, fracture, and treatment factors on mortality. RESULTS: A total of 1,109 patients were included. The in-hospital mortality rate was 5.3%. Multivariable analyses suggested that age, male sex, abbreviated mental test score (AMTS), pneumonia, renal failure, history of peripheral vascular disease (PVD) and deep surgical site infection were each independently associated with mortality. Each yearly increase in age independently correlates with a 7% increase in mortality (OR 1.07, p=0.019). The odds of mortality was 2.99 times higher for patients diagnosed with pneumonia during their hospital stay [OR 2.99 (95% CI 1.07-8.37) p=0.037], and 7.25 times higher for patients that developed renal failure during their stay [OR 7.25 (95% CI 1.85-28.47) p=0.005]. Patients with history of PVD have a six-fold greater mortality risk (OR 6.06, p=0.003). Mode of treatment was not a significant predictor of mortality. CONCLUSION: The in-hospital mortality rate of PPFs around the hip exceeds 5%. The fracture subtype and mode of management are not independent predictors of mortality, while patient factors such as age, AMTS, history of PVD, pneumonia, and renal failure can independently predict mortality. Peri-operative optimisation of modifiable risk factors such as lung and kidney function in patients with PPFs around the hip during their hospital stay is of utmost importance.


Assuntos
Artroplastia de Quadril , Fraturas do Quadril , Doenças Vasculares Periféricas , Fraturas Periprotéticas , Pneumonia , Insuficiência Renal , Adulto , Humanos , Masculino , Estudos Retrospectivos , Estudos de Coortes , Artroplastia de Quadril/efeitos adversos , Doenças Vasculares Periféricas/cirurgia , Reoperação
5.
J Transplant ; 2023: 8865364, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37810405

RESUMO

Pakistan is the fifth most populous country with a population of 225 million and has health expenditure accounting for only 2.8 percent of gross domestic product (GDP). Accordingly, there are a limited number of haematology-oncology and transplant centers in the country. The Pakistan Blood and Marrow Transplant (PBMT) group was established in 2020, and this report is the first activity survey from January 2021 to December 2022 focusing on the trends of matched-related donor, haploidentical, and autologous transplants in a developing country. A total of 12 transplant centers contributed data on the modified PBMT survey form retrospectively and 806 haematopoietic stem cell transplants (HSCTs) were carried out during the study duration. Allogeneic HSCT constituted 595 (73.8%) of all the transplants; this is in stark contrast to Western data, where autologous HSCT accounts for the majority of transplants. ß-thalassemia major and aplastic anemia were the commonest indications for allogeneic HSCT, in contrast to Western data, where acute leukemia is the leading transplant indication. Autologous transplants were more frequently performed for Hodgkin's lymphoma as compared to non-Hodgkin's lymphoma and multiple myeloma. The use of peripheral and bone marrow stem cells was comparable. A myeloablative conditioning regimen was routinely used in patients with acute leukemia. This report provides an insight of HSCT trends in Pakistan which are different from those of Western centers contributing to transplant data from South Asia.

6.
Sensors (Basel) ; 23(9)2023 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-37177468

RESUMO

Numerous sensitive applications, such as healthcare and medical services, need reliable transmission as a prerequisite for the success of the new age of communications technology. Unfortunately, these systems are highly vulnerable to attacks like Sybil, where many false nodes are created and spread with deceitful intentions. Therefore, these false nodes must be instantly identified and isolated from the network due to security concerns and the sensitivity of data utilized in healthcare applications. Especially for life-threatening diseases like COVID-19, it is crucial to have devices connected to the Internet of Medical Things (IoMT) that can be believed to respond with high reliability and accuracy. Thus, trust-based security offers a safe environment for IoMT applications. This study proposes a blockchain-based fuzzy trust management framework (BFT-IoMT) to detect and isolate Sybil nodes in IoMT networks. The results demonstrate that the proposed BFT-IoMT framework is 25.43% and 12.64%, 12.54% and 6.65%, 37.85% and 19.08%, 17.40% and 8.72%, and 13.04% and 5.05% more efficient and effective in terms of energy consumption, attack detection, trust computation reliability, packet delivery ratio, and throughput, respectively, as compared to the other state-of-the-art frameworks available in the literature.


Assuntos
Blockchain , COVID-19 , Internet das Coisas , Humanos , Lógica Fuzzy , Reprodutibilidade dos Testes , Confiança
7.
Urol Ann ; 15(1): 54-59, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37006206

RESUMO

Background: False-positive (FP) multiparametric magnetic resonance imaging (MPMRI) obscures and swift needless biopsies in men with a high prostate-specific antigen. Materials and Methods: This was a retrospective study, in which all patients who had been exposed to consecutive MP-MRI of the prostate combined with transrectal ultrasound-guided-magnetic resonance imaging fusion-guided prostate biopsy between 2017 and 2020 were involved in the study. The FP was measured as the number of biopsies that did not encompass prostate cancer divided by the whole number of biopsies. Results: The percentage of FP cases was 51.1%, the highest percentage was found in Prostate Imaging-Reporting and Data System (PI-RADs) 3 (37.7%) and the lowest was detected in PI-RAD 5 (14.5%). Those with FP biopsies are younger, and their total prostate antigen (PSA) and PSA density (PSAD) are significantly lesser. The area under the curve PSAD, age, and total PSA are 0.76, 0.74, and 0.69, respectively. An optimum PSAD value of 0.135 was chosen as a cutoff because it showed the highest sum of sensitivity and specificity, 68% and 69%, respectively. Conclusion: FP results of mpMRI were detected in more than half of our sample, more than one-third were presented in Pi-RAD3, improved imaging techniques to decrease FP rates are highly needed.

8.
Sensors (Basel) ; 22(18)2022 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-36146190

RESUMO

In vehicular ad hoc networks (VANETs), helpful information dissemination establishes the foundation of communication. One of the significant difficulties in developing a successful dissemination system for VANETs is avoiding traffic fatalities. Another essential success metric is the transfer of reliable and secure warning messages through the shortest path, particularly on highways with high mobility. Clustering vehicles is a general solution to these challenges, as it allows warning alerts to be re-broadcast to nearby clusters by fewer vehicles. Hence, trustworthy cluster head (CH) selections are critical to decreasing the number of retransmissions. In this context, we suggest a clustering technique called Optimal Path Routing Protocol for Warning Messages (OPRP) for dissemination in highway VANETs. OPRP relies on mobility measured to reinforce cluster creation, evade transmission overhead, and sustain message authenticity in a high mobility environment. Moreover, we consider communication between the cluster heads to reduce the number of transmissions. Furthermore, the cluster head is chosen using the median technique based on an odd or even number of vehicles for a stable and lengthy cluster life. By altering traffic densities and speeds, OPRP is compared with prominent schemes. Simulation results revealed that OPRP offers enhanced throughput, end-to-end delay, maximizing packet delivery ratio, and message validity.

9.
PeerJ Comput Sci ; 7: e707, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34712793

RESUMO

The traditional methods used for the identification of individuals such as personal identification numbers (PINs), identification tags, etc., are vulnerable as they are easily compromised by the hackers. In this paper, we aim to focus on the existing multibiometric systems that use hand based modalities for the identification of individuals. We cover the existing multibiometric systems in the context of various feature extraction schemes, along with an analysis of their performance using one of the performance measures used for biometric systems. Later, we cover the literature on template protection including various cancelable biometrics and biometric cryptosystems and provide a brief comment about the methods used for multibiometric template protection. Finally, we discuss various open issues and challenges faced by researchers and propose some future directions that can enhance the security of multibiometric templates.

10.
Saudi Med J ; 42(6): 649-654, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34078727

RESUMO

OBJECTIVES: To compare transperineal biopsies (TPBx) with transrectal ultrasound-guided biopsy (TRUSBx) in order to provide evidence, making clinicians able to select the appropriate biopsy approach under different conditions. METHODS: A comparative prospective study, conducted in King Khalid University Hospital (KKUH) and King Faisal Specialist Hospital and Research Centre (KFSH&RC), Riyadh, Kingdom of Saudi Arabia, between March 2019 and February 2020. All patients with raised prostate-specific antigen or atypical digital rectal examination findings were subjected to multi-parametric magnetic resonance imaging (MRI). Those with positive findings were referred to targeted fusion- guided biopsy either TPBx or TRUSBx, randomly. Complication rate, cancer detection rate, and procedure time were recorded. RESULTS: Transperineal biopsies and TRUSBx had an equivalent complication rate. However, both case detection rate and clinically significant cancer detection rate were significantly higher in TPBx versus TRUSBx (45.1% versus 29.1%, p=0.003; and 71.8% versus 43.7%, p=0.002; respectively). Transperineal biopsies was a longer procedure than TRUSBx (41.2±0.7 min versus 13±2.3 min, p=0.0001). CONCLUSION: No difference in complication rate was detected between the 2 procedures; however, TPBx was more effective for cancer detection in general and clinically significant cancer detection in particular.


Assuntos
Neoplasias da Próstata , Humanos , Biópsia Guiada por Imagem , Imageamento por Ressonância Magnética , Masculino , Estudos Prospectivos , Neoplasias da Próstata/diagnóstico por imagem , Ultrassonografia de Intervenção
11.
Sensors (Basel) ; 21(1)2020 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-33375153

RESUMO

A multitude of smart things and wirelessly connected Sensor Nodes (SNs) have pervasively facilitated the use of smart applications in every domain of life. Along with the bounties of smart things and applications, there are hazards of external and internal attacks. Unfortunately, mitigating internal attacks is quite challenging, where network lifespan (w.r.t. energy consumption at node level), latency, and scalability are the three main factors that influence the efficacy of security measures. Furthermore, most of the security measures provide centralized solutions, ignoring the decentralized nature of SN-powered Internet of Things (IoT) deployments. This paper presents an energy-efficient decentralized trust mechanism using a blockchain-based multi-mobile code-driven solution for detecting internal attacks in sensor node-powered IoT. The results validate the better performance of the proposed solution over existing solutions with 43.94% and 2.67% less message overhead in blackhole and greyhole attack scenarios, respectively. Similarly, the malicious node detection time is reduced by 20.35% and 11.35% in both blackhole and greyhole attacks. Both of these factors play a vital role in improving network lifetime.

12.
Sensors (Basel) ; 20(21)2020 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-33121033

RESUMO

In this paper, we investigate the problem of selective routing attack in wireless sensor networks by considering a novel threat, named the upstream-node effect, which limits the accuracy of the monitoring functions in deciding whether a monitored node is legitimate or malicious. To address this limitation, we propose a one-dimensional one-class classifier, named relaxed flow conservation constraint, as an intrusion detection scheme to counter the upstream node attack. Each node uses four types of relaxed flow conservation constraints to monitor all of its neighbors. Three constraints are applied by using one-hop knowledge, and the fourth one is calculated by monitoring two-hop information. The latter is obtained by proposing two-hop energy-efficient and secure reporting scheme. We theoretically analyze the security and performance of the proposed intrusion detection method. We also show the superiority of relaxed flow conservation constraint in defending against upstream node attack compared to other schemes. The simulation results show that the proposed intrusion detection system achieves good results in terms of detection effectiveness.

13.
J Healthc Eng ; 2020: 8017496, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32509260

RESUMO

The developing countries are still starving for the betterment of health sector. The disease commonly found among the women is breast cancer, and past researches have proven results that if the cancer is detected at a very early stage, the chances to overcome the disease are higher than the disease treated or detected at a later stage. This article proposed cloud-based intelligent BCP-T1F-SVM with 2 variations/models like BCP-T1F and BCP-SVM. The proposed BCP-T1F-SVM system has employed two main soft computing algorithms. The proposed BCP-T1F-SVM expert system specifically defines the stage and the type of cancer a person is suffering from. Expert system will elaborate the grievous stages of the cancer, to which extent a patient has suffered. The proposed BCP-SVM gives the higher precision of the proposed breast cancer detection model. In the limelight of breast cancer, the proposed BCP-T1F-SVM expert system gives out the higher precision rate. The proposed BCP-T1F expert system is being employed in the diagnosis of breast cancer at an initial stage. Taking different stages of cancer into account, breast cancer is being dealt by BCP-T1F expert system. The calculations and the evaluation done in this research have revealed that BCP-SVM is better than BCP-T1F. The BCP-T1F concludes out the 96.56 percentage accuracy, whereas the BCP-SVM gives accuracy of 97.06 percentage. The above unleashed research is wrapped up with the conclusion that BCP-SVM is better than the BCP-T1F. The opinions have been recommended by the medical expertise of Sheikh Zayed Hospital Lahore, Pakistan, and Cavan General Hospital, Lisdaran, Cavan, Ireland.


Assuntos
Neoplasias da Mama/diagnóstico , Mama/diagnóstico por imagem , Computação em Nuvem , Diagnóstico por Computador , Computação em Nuvem/estatística & dados numéricos , Diagnóstico por Computador/estatística & dados numéricos , Detecção Precoce de Câncer , Sistemas Especialistas , Feminino , Humanos , Máquina de Vetores de Suporte
14.
Sensors (Basel) ; 19(14)2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31311136

RESUMO

The industrial control systems are facing an increasing number of sophisticated cyber attacks that can have very dangerous consequences on humans and their environments. In order to deal with these issues, novel technologies and approaches should be adopted. In this paper, we focus on the security of commands in industrial IoT against forged commands and misrouting of commands. To this end, we propose a security architecture that integrates the Blockchain and the Software-defined network (SDN) technologies. The proposed security architecture is composed of: (a) an intrusion detection system, namely RSL-KNN, which combines the Random Subspace Learning (RSL) and K-Nearest Neighbor (KNN) to defend against the forged commands, which target the industrial control process, and (b) a Blockchain-based Integrity Checking System (BICS), which can prevent the misrouting attack, which tampers with the OpenFlow rules of the SDN-enabled industrial IoT systems. We test the proposed security solution on an Industrial Control System Cyber attack Dataset and on an experimental platform combining software-defined networking and blockchain technologies. The evaluation results demonstrate the effectiveness and efficiency of the proposed security solution.

15.
Sensors (Basel) ; 19(24)2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31888213

RESUMO

Underwater Wireless Sensors Networks (UWSNs) use acoustic waves as a communication medium because of the high attenuation to radio and optical waves underwater. However, acoustic signals lack propagation speed as compared to radio or optical waves. In addition, the UWSNs also pose various intrinsic challenges, i.e., frequent node mobility with water currents, high error rate, low bandwidth, long delays, and energy scarcity. Various UWSN routing protocols have been proposed to overcome the above-mentioned challenges. Vector-based routing protocols confine the communication within a virtual pipeline for the sake of directionality and define a fixed pipeline radius between the source node and the centerline station. Energy-Scaled and Expanded Vector-Based Forwarding (ESEVBF) protocol limits the number of duplicate packets by expanding the holding time according to the propagation delay, and thus reduces the energy consumption via the remaining energy of Potential Forwarding Nodes (PFNs) at the first hop. The holding time mechanism of ESEVBF is restricted only to the first-hop PFNs of the source node. The protocol fails when there is a void or energy hole at the second hop, affecting the reliability of the system. Our proposed protocol, Extended Energy-Scaled and Expanded Vector-Based Forwarding Protocol (EESEVBF), exploits the holding time mechanism to suppress duplicate packets. Moreover, the proposed protocol tackles the hidden terminal problem due to which a reasonable reduction in duplicate packets initiated by the reproducing nodes occurs. The holding time is calculated based on the following four parameters: (i) the distance from the boundary of the transmission area relative to the PFNs' inverse energy at the 1st and 2nd hop, (ii) distance from the virtual pipeline, (iii) distance from the source to the PFN at the second hop, and (iv) distance from the first-hop PFN to its destination. Therefore, the proposed protocol stretches the holding time difference based on two hops, resulting in lower energy consumption, decreased end-to-end delay, and increased packet delivery ratio. The simulation results demonstrate that compared to ESEVBF, our proposed protocol EESEVBF experiences 20.2 % lesser delay, approximately 6.66 % more energy efficiency, and a further 11.26 % reduction in generating redundant packets.

16.
BMJ Case Rep ; 20172017 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-28438753

RESUMO

Small bowel diverticulosis of the jejunum and ileum is an uncommon finding with a prevalence rate of 0.2% to 1.3% at autopsy and 0.3% to 1.9% on small bowel studies. Diagnosis can be difficult because there are no pathognomonic features or clinical symptoms that are specific for small bowel diverticulosis. Though rare, it is critical to keep the possibility of small bowel diverticulosis in mind when evaluating cases of malabsorption, chronic abdominal pain, haemorrhage, perforation and intestinal obstruction, especially in patients with connective tissue disorders, a family history of diverticula and a personal history of colonic diverticulosis. Guidelines for the treatment of complicated small bowel diverticulosis are not clearly defined. However, the consensus in treatment is to do a small bowel resection with primary anastomosis. We report three interesting cases of jejunoileal diverticula that presented in an occult manner and later progressed to more emergent manifestations.


Assuntos
Doenças Diverticulares/diagnóstico , Doenças do Íleo/diagnóstico , Intestino Delgado , Doenças do Jejuno/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Diagnóstico por Imagem , Progressão da Doença , Doenças Diverticulares/patologia , Doenças Diverticulares/terapia , Feminino , Humanos , Doenças do Íleo/patologia , Doenças do Íleo/terapia , Doenças do Jejuno/patologia , Doenças do Jejuno/terapia , Masculino
17.
BMJ Case Rep ; 20172017 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-28143859

RESUMO

In ∼60% of cases, hepatic artery anatomy is of the normal variant. However, in 40% of cases, anomalies can exist. Preserving the hepatic blood supply is paramount in hepatobiliary procedures. We report an aberrant right hepatic artery coursing retroportally, with an aberrant left hepatic artery originating directly from the coeliac artery in a patient who underwent an elective pancreaticoduodenectomy (Whipple procedure).


Assuntos
Variação Anatômica , Neoplasias dos Ductos Biliares/cirurgia , Artéria Celíaca/anormalidades , Colangiocarcinoma/cirurgia , Artéria Hepática/anormalidades , Pancreaticoduodenectomia , Artéria Esplênica/anormalidades , Artéria Celíaca/diagnóstico por imagem , Angiografia por Tomografia Computadorizada , Feminino , Artéria Hepática/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Artéria Esplênica/diagnóstico por imagem
18.
J Infect Public Health ; 9(4): 443-51, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26688375

RESUMO

Our objective was to evaluate the impact of using an imipenem de-escalation protocol for empiric febrile neutropenia on the development of carbapenem resistance. A pre-post intervention design was used. The intervention was adopting the imipenem de-escalation approach, which began on January 1, 2012. A retrospective chart review of cases of febrile neutropenia bacteremia was performed one year before and one year after the intervention. We compared the development of carbapenem resistance between the two study periods. Seventy-five episodes of febrile neutropenia bacteremia were included in the study. They had similar demographics, clinical features and outcomes. There were 78 and 12 pathogens in the primary and follow-up blood cultures, respectively. Approximately 61% and 66% of the primary and follow-up blood cultures, respectively, were gram-negative bacteria with similar carbapenem resistance profiles in the two study periods. In our study population, 57% of the gram-negative bacteria were ESBL pathogens. The resistance of the gram-negative bacteria to piperacillin/tazobactam (72% versus 53%, p=0.161), imipenem (16% versus 11%, p=0.684), and meropenem (8% versus 16%, p=0.638) did not significantly change after our policy change. In conclusion, the use of the carbapenem de-escalation approach for febrile neutropenia in our institution was not associated with an increase in carbepenem resistance. Future prospective multi-center studies are recommended to further confirm the current findings.


Assuntos
Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Uso de Medicamentos , Neutropenia Febril/tratamento farmacológico , Bactérias Gram-Negativas/efeitos dos fármacos , Imipenem/uso terapêutico , Resistência beta-Lactâmica , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ensaios Clínicos Controlados não Aleatórios como Assunto , Prevalência
19.
J Med Syst ; 39(10): 115, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26280322

RESUMO

Advances in wearable and implantable biosensors have enabled the applicability and usability of wireless body area networks (WBANs). A WBAN allows biosensors to collect and communicate human physiological data using wireless communication. The communication security of the collected data in WBAN is a major concern. Because of the dependability of cryptographic schemes for key management, these have become an important aspect of this security. However, the extremely constrained nature of biosensors has made designing key management schemes a challenging task. For this reason, many lightweight key management schemes have been proposed to overcome these constraints. In this article, we present a review of the state of the art of these solutions. We classify the WBAN schemes into three classes and evaluate them based on adequate metrics for key management in WBAN.


Assuntos
Redes de Comunicação de Computadores/instrumentação , Segurança Computacional/instrumentação , Monitorização Ambulatorial/instrumentação , Telemetria/instrumentação , Humanos , Tecnologia sem Fio
20.
J Med Syst ; 38(5): 33, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24744081

RESUMO

Information and communication technologies have thrived over the last few years. Healthcare systems have also benefited from this progression. A wireless body area network (WBAN) consists of small, low-power sensors used to monitor human physiological values remotely, which enables physicians to remotely monitor the health of patients. Communication security in WBANs is essential because it involves human physiological data. Key agreement and authentication are the primary issues in the security of WBANs. To agree upon a common key, the nodes exchange information with each other using wireless communication. This information exchange process must be secure enough or the information exchange should be minimized to a certain level so that if information leak occurs, it does not affect the overall system. Most of the existing solutions for this problem exchange too much information for the sake of key agreement; getting this information is sufficient for an attacker to reproduce the key. Set reconciliation is a technique used to reconcile two similar sets held by two different hosts with minimal communication complexity. This paper presents a broadcast-based key agreement scheme using set reconciliation for secure communication in WBANs. The proposed scheme allows the neighboring nodes to agree upon a common key with the personal server (PS), generated from the electrocardiogram (EKG) feature set of the host body. Minimal information is exchanged in a broadcast manner, and even if every node is missing a different subset, by reconciling these feature sets, the whole network will still agree upon a single common key. Because of the limited information exchange, if an attacker gets the information in any way, he/she will not be able to reproduce the key. The proposed scheme mitigates replay, selective forwarding, and denial of service attacks using a challenge-response authentication mechanism. The simulation results show that the proposed scheme has a great deal of adoptability in terms of security, communication overhead, and running time complexity, as compared to the existing EKG-based key agreement scheme.


Assuntos
Redes de Comunicação de Computadores/organização & administração , Tecnologia de Sensoriamento Remoto/métodos , Processamento de Sinais Assistido por Computador/instrumentação , Telemetria/métodos , Tecnologia sem Fio/organização & administração , Algoritmos , Humanos
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